Predictive value of multimodal ultrasound characteristics on Ki-67 and CMTM6 expression in breast cancer

CANG Qing; YE Xinhua; ZHANG Aihua

Abstract：Objective To investigate the predictive value of multimodal ultrasound features for Ki-67 and chemokine like fac-tor MARVEL transmembrane domain containing 6(CMTM6)expression in breast cancer.Methods 145 breast cancer patients who received surgical treatment were examined by conventional ultrasound,shear wave elastography(SWE)and contrast-enhanced ultrasound(CEUS)before surgery.The expression of Ki-67 and CMTM6 was detected by immunohistochemistry.Multi-variate logistic regression analysis was used to analyze the predictive value of multimodal ultrasound features on Ki-67 and CMTM6 expression.Results The positive rates of Ki-67 and CMTM6 in breast cancer tissues were 90.34%(131/145)and 88.97%(129/145),respectively,which were higher than those in normal breast tissues adjacent to cancer 9.66%(14/145)and 11.03%(16/145)(χ2=198.7,199.1,P<0.001).The tumor shape,tumor boundary and microcalcification in conventional ultra-sound were related to the expression of Ki-67 and CMTM6 in breast cancer(all P<0.05).The hard ring sign and black hole sign in SWE were related to the expression of Ki-67 and CMTM6 in breast cancer(P<0.05).The early enhancement and late regres-sion perfusion of CEUS characteristics were related to the expression of Ki-67 and CMTM6 in breast cancer(P<0.05).Logistic re-gression analysis showed that irregular tumor shape,unclear boundary,microcalcification,hard ring sign,black hole sign,early enhancement and late regression perfusion were independent predictors of Ki-67 and CMTM6 positive expression in breast cancer.Conclusion Multimodal ultrasound features can be used to predict the expression of Ki-67 and CMTM6 in breast can-cer,which is helpful for the diagnosis and treatment of breast cancer.