Analysis of the value of transcranial sonography of the substantia nigra and magnetic resonance imaging for Parkinson's disease

XIE Qingqing; HU Chunfeng

Abstract：Objective This study aimed to investigate the value of transcranial sonography(TCS)of the substantia nigra(SN)and magnetic resonance imaging(MRI)in the diagnosis of Parkinson's disease(PD).Methods Overall,121 patients with PD from our hospital and 121 healthy individuals who underwent medical checkups in the same period were selected as the observation and control groups,respectively,all of whom received TCS of the SN and MRI.The TCS(ratio of total hyperechoic substantia nigra area to total midbrain area,S/M),hyperechoic substantia nigra area and MRI parameters(midbrain diameter,width of pars compacta of substantia nigra,WPCSN),WPCSN/midbrain diameter were collected for the analysis of the relation-ship between the Hoehn-Yahr scale and TCS parameters of the SN and MRI.Results The observation group had higher S/M and total hyperechoic substantia nigra area and lower WPCSN and WPCSN/midbrain diameter values than the control group(P<0.05).The S/M,total hyperechoic substantia nigra area,WPCSN,and WPCSN/midbrain diameter values had significant differ-ences between patients of different Hoehn-Yahr scale in the observation group(P<0.05).Spearman's test confirmed a positive correlation between S/M,total hyperechoic substantia nigra area,and Hoehn-Yahr scale and a negative correlation between WPCSN,WPCSN/midbrain diameter,and Hoehn-Yahr scale(P<0.05).Conclusion The cranial characteristics of patients with PD can be distinguished by TCS of the SN and MRI,and its parameters show significant differences between patients with PD of different Hoehn-Yahr scale.