The value of multimodal MRI in IDH genotyping of glioma

XIONG Ruifang; ZHU Hanting; LI Chengyi; TANG Xiaoping

Abstract：Objective To find MRI features that noninvasively reflect the cell proliferation,and IDH genotype of glioma.Methods We retrospectively analyzed 120 patients with glioma confirmed by postoperative pathology in our hospital.MRI ex-aminations included head routine scans,enhanced scans,DWI,DTI,MRS,and 3D ASL.Immunohistochemistry was applied to detect Ki-67 expression in glioma,and PCR sequencing was applied to detect IDH1 and P53 mutations in glioma.All data were analyzed by SPSS26.0 statistical software,and the difference was considered statistically significant at P<0.05.Results Ki-67 labeling index was positively correlated with enhancement,peritumoral edema,nature,age,pathological grade and rCBF value in tumor area and edema area(P<0.05).The degree of enhancement,T2-FLAIR mismatch sign,tumor area and edema area rCBF value,rADCmin value in the tumor area and Cho/NAA ratio in the tumor area were statistically different between IDH1mut and IDH1wild glioma groups(P<0.05).The P53 mutation status of glioma was statistically significant with respect to gen-der,nature,rCBF value in the tumor area and rFAmean(P<0.05).Conclusion Preoperative tumor area rCBF value can help glioma IDH1 genotyping and predict the degree of Ki-67 gene expression.T2-FLAIR mismatch sign and rCBF value can be MRI features to evaluate IDH1 genotype.