Specific changes of white matter fiber bundles in children with spinal cord injury without fracture and dislocation:tract-based spatial statistics
ZHENG Weimin
WANG Ling
YANG Beining
LI Kuncheng
LU Jie
CHEN Nan
Abstract：Objective To investigate the specific changes of white matter fiber tracts in children with spinal cord injury with-out fracture and dislocation(SCIWOFD).Methods Diffusion tensor imaging(DTI)data were obtained from 25 children with SCIWOFD and 27 age-and gender-matched healthy controls(HCs).Tract-based spatial statistics(TBSS)was used to analyze the differences of white matter fiber tracts between the two groups,the correlation between white matter fiber bundle changes and clinical indicators in children with SCIWOFD was further quantitatively analyzed.Finally,receiver operating characteristic curve(ROC)analysis was used to calculate the sensitivity and specificity of TBSS in the diagnosis of children with SCIWOFD.Re-sults Compared with HCs,children with SCIWOFD showed significantly increased fractional anisotropy(FA)in the right supe-rior longitudinal fasciculus,left splenium of the corpus callosum,and right posterior limb of the internal capsule,as well as sig-nificantly decreased mean diffusivity(MD)and radial diffusivity(RD).No significant correlations were found between DTI-related indicators and sensory motor scores,patient age,or disease duration.When using the FA value of the right superior longi-tudinal fasciculus as a classification indicator for the two groups,the area under the curve(AUC)value reached 0.903.Conclu-sions There are significant white matter fiber bundle changes in children with SCIWOFD,and TBSS has certain potential as a screening tool for children with SCIWOFD,which provides a new perspective for future rehabilitation treatment.
Keywords：Pediatric spinal cord injury without fracture or dislocationTract-based spatial statisticsWhite matter fiber tractsReceiver operating characteristic curveMagnetic resonance imaging
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1-6 )