A BOLD MRI study of renal oxygenation levels in type2 diabetic patients with renal impairment
ZHENG Shuangshuang
HE Yueming
GAO Zhiyuan
ZHANG ying
Abstract：Objective To investigate the changes in renal hypoxia at different levels of estimated glomerular filtration rate(eGFR)in patients with type 2 diabetes by BOLD MRI.Methods 64 patients with type 2 diabetes mellitus(DM group)and 14 normal controls(NC group)underwent BOLD MRI examination.According to eGFR,diabetic patients were divided into nor-mal eGFR group(group A),mild and moderate to severe renal impairment group(group B and group C).Renal medullary R2*(MR R2*)and cortical R2*(CR2*)were measured.The inter-group differences of MR2* and CR2* were analyzed by one-way ANOVA.The relationship was analyzed between R2* and eGFR values and the receiver operating characteristic curve was used to assess the MR2* and CR2* values on renal function impairment in patients with type 2 diabetes.Results Compared with the NC group,the values of medullary R2* and cortical R2* in groups A,B and C were significantly increased(all P<0.05),and were positively correlated with eGFR(all P<0.05).MR2* and CR2* values may identify type 2 diabetic patients from normal controls,but the sensitivity of the MR2* value was slightly higher.Conclusion BOLD MRI can noninvasively evaluate the early renal functional hypoxia changes in diabetic patients and monitor the renal oxygenation level at different stages of eGFR,which has guiding significance for clinical treatment.
Keywords：Diabetes mellitus type 2Estimated glomerular filtration rateBlood oxygen level dependentMagnetic reso-nance imaging
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 65-69 )