Evaluation of the safety and efficacy of fine TACE combined with the cyberknife in the treatment of unresectable liver malignant tumors
WANG Guanwu
LYU Qingliang
TANG Shiwei
LI Wenjun
LIU Quan
JIANG Nan
HE Guanghui
KONG Mingxin
LI Yan
CAI Jia
Abstract：Objective To evaluate the safety and efficacy of fine TACE combined with the cyberknife in the treatment of unre-sectable liver malignant tumors.Methods Forty-six patients with advanced unresectable hepatic malignancies were divided into control group(31 cases)and combination group(15 cases).The patients in control group were treated with TACE alone or-with cyberknife alone,while,patients in the combined treatment group were treated with TACE+cyberknife.During TACE sur-gery,embolization was performed after microcatheter superselection and conical beam CT verification.Progression-free survival(PFS),overall survival(OS),adverse reactions(CTCAE5.0),albumin-bilirubin score(ALBI),D-2 polymers and quality of life(KPS)scores were observed.Results The PFS of the combined group was 10.13(2.0,27.0)months,higher than 4.70(1.0,18.0)months of the control group,and the difference was statistically significant(f=8.131,P=0.010).The ORR and DCR of the combined group were 47.7%and 86.7%,respectively,higher than 38.7%and 74.2%of the control group,but the differ-ence was not statistically significant(P=0.500).The proportion of grade Ⅰ、Ⅱ and Ⅲ adverse reactions was 13.7%、5.8%and 2.4%,respectively.There was no significant difference in AFP,ALBI,D-2 and other related indexes between control group and combination group(P>0.05).Conclusion The efficacy of the combination group(TACE+cyberknife)in the treatment of unre-sectable hepatic malignancies is better than that of the reference group with TACE or cyberknife alone,and the safety is better.
Keywords：Hepatic malignant tumorCyberknifeSecurityEffectiveness
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 61-64 )