The analysis of diagnostic efficacy of MSCT combined with cancer factors for pulmonary tuberculosis combined with lung cancer

LI Li; JI Fengying; LIN Wei

Abstract：Objective To analyze the diagnostic efficacy of 64 Philips CT combined with pleiotropic protein(PTN),carcino-embryonic antigen(CEA),and cytokeratin 19 fragment(CYFRA21-1)in tuberculosis and lung cancer.Methods 76 tubercu-losis patients with suspected soft tissue mass were selected for observation.40 patients with simple tuberculosis by the pathologi-cal gold standard patients were infor group A,36 patients with tuberculosis with lung cancer were in group B,40 healthy volun-teers were in group C.Patients in the three groups were diagnosed by means of the combination of MSCT with PTN,CEA,CYFRA21-1.The cancer factors,CT characteristics were compared between different groups.The different lung cancer factors of patients in group B were analyzed and the predict value of the model was also evaluated by ROC curve analysis.Results 1)The PTN,CEA,and CYFRA21-1 levels in group B were significantly higher than those in groups A and C(P<0.05);2)PTN levels in small cell lung cancer were significantly higher than adenocarcinoma and squamous carcinoma(P<0.05),but,CEA and CYFRA21-1 levels in small cell lung cancer were significantly lower than adenocarcinoma and squamous carcinoma,adeno-carcinoma patients had significantly higher CEA levels(P<0.05);3)The number of vacuolation,calcification,foliation,burr,satellite focus,pleural depression and cavity sign were higher than group A,with statistically significant difference between groups(P<0.05);and 4)The ROC curve results showed that the optimal cut-off value of the prediction model was 0.089 and the area under the ROC curve(area under curve,AUC)was 0.614(0.651～0.732),0.671(0.686～0.811)and 0.891(0.787～0.993)(P<0.05).Conclusion MSCT combined with PTN、CEA and CYFRA21-1 has high diagnostic efficiency in tuberculosis and lung cancer,with significant differences between CT characteristics and sputum tumor marker levels.