The value of serum tumor markers combined with multilayer spiral CT in the diagnosis and prognosis of non-small cell lung cancer

YANG Lin; WANG Longying

Abstract：Objective To investigate the application value of serum tumor markers combined with multilayer spiral CT(MSCT)in the diagnosis and prognosis of non-small cell lung cancer(NSCLC).Methods 60 patients with NSCLC in our hos-pital were selected as the observation group,and another 60 patients with benign lung lesions were selected as the control group.We compared the serum tumor markers[alpha-fetoprotein(AFP),glycoantigen 125(CA125),neuron-specific enolase(NSE)]and MSCT perfusion imaging parameters[blood volume(BV),contrast time to peak(TTP),peak enhancement(PEI)]be-tween the two groups so as to evaluate the diagnostic value of serum tumor markers and MSCT perfusion imaging parameters on NSCLC.We analyzed the serum tumor markers and MSCT perfusion imaging parameters,divided NSCLC patients into low level and high level patients by the mean value of serum tumor markers and MSCT perfusion imaging parameters,compared the 3-year survival of NSCLC patients,and analyzed the effect of serum tumor markers and MSCT perfusion imaging parameters on the 3-year risk of death.Results Serum AFP,CA125,NSE levels and BV,PEI were higher in the observation group than those in the control group(P<0.05);serum AFP,CA125,NSE levels of NSCLC patients were positively correlated with MSCT quantita-tive parameters,i.e.,BV and PEI(P<0.05);ROC curves were plotted,and the results showed that the AUCs of serum tumor markers,AFP,CA125,NSE and MSCT perfusion imaging parameters,BV and PEI,were 0.763,0.833,0.709,0.816,0.714,respectively,and the combined diagnostic AUC was 0.932,which was significantly higher than the diagnostic value of each in-dex alone;the AUC of serum AFP,CA125,NSE and MSCT quantitative parameters,BV and PEI,were 0.763,0.833,0.709,0.816,0.714 and 0.932,respectively.The 3-year morbidity and mortality rate was higher in patients with high levels than those with low levels(P<0.05);the 3-year risk of death was 3.167,5.654,2.953,3.860 and 4.144 times higher in patients with high levels of serum AFP,CA125,NSE and MSCT quantitative parameters BV and PEI than in patients with low levels.Conclu-sion The values of serum tumor markers and MSCT parameters(BV and PEI)are significantly higher in NSCLC patients,and they are closely related,which can diagnose NSCLC non-invasively and accurately,predict survival,and enable patients to re-ceive early diagnosis and effective treatment,thus improving prognosis.