Application of three-dimensional magnetic resonance arterial spin labeling imaging in the evaluation of hemodynamics and prognosis in patients with vascular cognitive impairment

FAN Lingyan; XING Guoping; WU Xiaoli; YU Haining; GUO Guocai

Abstract：Objective To investigate the application value of three-dimensional magnetic resonance arterial spin labeling im-aging in the evaluation of hemodynamics and prognosis of patients with vascular cognitive impairment.Methods The clinical data of 60 patients with ischemic small cerebral vascular disease admitted were retrospectively analyzed.They were divided into cognitive impairment group(30 cases)and cognitive normal group(30 cases).MoCA scale was used to assess cognitive function.3D-ASL brain perfusion imaging was performed by different PLDS(1.5 and 2.5 s).The mirror symmetry measurement(CBF1.5 and CBF2.5)was performed on bilateral frontal lobe,temporal lobe,parietal lobe,hippocampus and temporoparietal junction us-ing GE AW4.5 workstation.The differences of WMLs score between the two groups were compared,and the correlation between WMLs score/MoCA scale score and CBF in each brain area was analyzed.Results WMLs score in the cognitive impairment group was significantly higher than that in the cognitive normal group,and the difference was statistically significant(P<0.05).Compared with the cognitive normal group,the CBF1.5 values of the bilateral frontal lobe,temporal lobe,parietal lobe,hippo-campus and temporoparietal junction were significantly lower in the cognitive impairment group,while the CBF2.5 values of the bi-lateral frontal lobe,temporal lobe and hippocampus were significantly lower in the cognitive impairment group,with statistical significance(P<0.05).Under different PLD,the difference of CBF1.5 and CBF2.5 values in bilateral frontal lobe of cognitive im-pairment group was statistically significant(P<0.05).CBF1.5 of bilateral frontal,temporal and hippocampal lobes and CBF2.5 of bilateral frontal,hippocampal and left temporal lobes were significantly positively correlated with MoCA scores.Conclusion In 3D-ASL technique,the sensitivity of detecting cerebral hypoperfusion in VCI patients is higher under PLD=1.5 s index,while,the specificity is higher under PLD=2.5 s index.WMLs is positively correlated with VCI severity.