MRI and clinical manifestations of autoimmune glial fibrillary acidic protein astrocytopathy
MA Junnan
JIANG Chuanwu
LI Houying
LIU Ping
Abstract：Objective To investigate the imaging characteristics and clinical diagnosis of autoimmune glial fibrillary acidic proteinastrocytopathy(GFAP-A).Methods The magnetic resonance(MR)images of 5 patients with clinically confirmed GFAP-A were retrospectivelyanalyzed,and literatures were reviewed.Results Among the 5 patients,4 underwent cranial MR plain scan and enhanced scan,4 underwent spinalMR plain scan and enhanced scan,and 1 underwent spinal MR plain scan.In the 5 cases of GFAP-A,the brain MR image lesions mainly located in the cerebellum and periventricular white matter.After contrastin-jection,the MR images showed that the lesions were radial lineargadolinium enhancement in the cerebellum and linear gadolini-umenhancement in the white matter perpendicular to the ventricle in 2patients.Spine MRI images revealed longitudinally exten-sive spinalcord lesions.The lesions showed hyperintensity on T2WI.On enhanced scan,the lesions were slightly enhanced.Conclusion GFAP-A is relatively rare.Clinical manifestations are lack of specificity.MR examination has great clinical value.Combined with laboratory examination can improve the diagnostic accuracy and avoid misdiagnosis.
Keywords：Autoi mmune glial fibrillary acidic protein astrocytopathyMagnetic resonance imagingDiagnosis
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 27-30 )