CT-guided hematoma drainage combined with edaravone in treating hypertensive intracerebral hemorrhage:effect ob-servation

MA Xiaoxuan; RUAN Weisheng; SHI Biao; ZHAO Chunlong; LYU Chao

Abstract：Objective To observe the clinical effect of CT-guided hematoma drainage combined with edaravone in treating hypertensive intracerebral hemorrhage(HICH).Methods A total of 82 patients with HICH treated in our hospital from March 2021 to March 2023 were selected and randomly divided into a control group(n=41)and a treatment group(n=41)according to a random number table method.All subjects underwent CT-guided hematoma drainage and received routine symptomatic and sup-portive treatment.In addition,the treatment group was treated with edaravone,and both groups received continuous treatment for 3 courses.The overall therapeutic effect and occurrence of adverse reactions during the treatment were recorded.The Barthel In-dex(BI)scores,National Institutes of Health Stroke Scale(NIHSS)scores,inflammation response,oxidative damage index lev-els,and changes in CT features of both groups were measured before and after treatment.Results After treatment,the total ef-fective rate in the treatment group was 95.12%,which was higher than that in the control group(78.05%),and the difference be-tween the two groups was statistically significant(χ2=5.145,P=0.023);both groups showed a significant increase in BI scores,with the treatment group higher than the control group.In addition,IL-8,PTX3,VCAM1,MAD,IMA,ROS,and NIHSS scores were significantly reduced in both groups,with the treatment group lower than the control group(P<0.05).After treat-ment,the bleeding volume,midline displacement,and number of cases of hematoma enlargement in the treatment group were significantly lower than those in the control group(P<0.05).Moreover,there was no statistically significant difference in the inci-dence of adverse reactions between the two groups(P>0.05).Conclusion CT-guided hematoma drainage combined with edara-vone can significantly improve the inflammatory and oxidative damage status of HICH patients,further alleviate clinical symp-toms,improve quality of life and neurological function,and achieve significant therapeutic effects.