A preliminary study on the changes of cerebellar microstructure and metabolism in patients with Parkinson's frozen gait by amino proton transfer imaging

NIE Congke; LIN Weilong; MA Jingxu

Abstract：Objective To investigate the clinical value of amino proton transfer(APT)and diffusion tensor image(DTI)in the changes of cerebellar microstructure in patients with Parkinson's disease(PD).Methods 46 patients with PD in our hospi-tal were selected for amino proton transfer imaging and diffusion tensor imaging,and 48 patients were selected as the control group.According to amino proton transfer imaging and diffusion tensor imaging,MTR and FA values of the region of interest were measured respectively,and the differences between groups were analyzed.T-test was used to evaluate whether its param-eters had certain diagnostic value for PD.Compared with results of the control group,the FA value and ADC value of cerebellar white matter in PD patients decreased,and the ADC value increased statistically(P<0.001);the FA value of dentate nucleus in PD patients was lower than that in the control group,and the MTR value was higher than that in the control group(P<0.001).Results Compared with the control group,the FA value and ADC value of cerebellar white matter in PD patients decreased,and the ADC value increased statistically(P<0.001);the FA value of dentate nucleus in PD patients was lower than that in the control group,and the MTR value was higher than that in the control group(P<0.001).In ROC analysis,the dentate nucleus and substantia nigra had certain diagnostic accuracy in PD patients(P<0.05),while the cerebellar medulla,dentate nucleus,and substantia nigra have certain diagnostic accuracy in FA for PD patients(P<0.05).Conclusion Amino proton transfer imaging can reflect the changes of cerebellar microstructure metabolism in patients with Parkinson's frozen gait,and its reference value can be used as an evaluation index for patients with PD.