Comparative study of transient elastography in the diagnosis of hepatitis B and autoimmune liver disease

WANG Guoying; SONG Yanli; LIU Chao; LI Pei; WANG Min

Abstract：Objective To explore the comparative value of transient elastography(FT)in the diagnosis of hepatitis B and au-toimmune liver disease.Methods A total of 59 patients with hepatitis B(Group A)and 31 patients with primary biliary cholan-gitis(Group B)admitted to our hospital were selected.Patients of both groups underwent liver biopsy and pathological examina-tion to obtain the stages of fibrosis;FT examination was performed on patients of two groups to obtain the liver stiffness value(LSM)of patients of the two groups,and an attempt was made to analyze the correlation and difference between the liver stiff-ness value and the stage of pathological fibrosis.Results The degree of hepatocyte inflammation and liver fibrosis in patients of the two groups tended to be consistent.Pearson analysis showed that there was a positive correlation between the degree of inflam-mation and fibrosis(P<0.05);The liver hardness values of patients with no fibrosis,mild to moderate,and severe fibrosis in the two groups showed an upward trend.The more severe the pathological stage was,the greater the LSM was,and the difference in LSM among different pathological stages was statistically significant(t=234.599,321.819 both P<0.001);LSM of patients with-out fibrosis,moderate to mild and severe fibrosis in Group A was lower than that in Group B,with no statistically significant dif-ference in S0 stage(t=1.780;P=0.079);The difference between S1～S2 and S3～S4 stages was statistically significant(t=8.352,6.392;P<0.001).Conclusion FT is an effective noninvasive and quantitative method for assessing the degree of liver fibrosis in patients with liver diseases,providing scientific basis for clinical diagnosis and treatment;The higher the degree of liver fibro-sis,the higher the LSM is indicated by FT examination;Under the same pathological stage,there are differences in LSM be-tween patients with hepatitis B and primary biliary cholangitis;In the future,we can try to establish a reference standard for liver damage in FT examination of patients with different types of hepatitis.