Evaluation of left ventricular systolic function in patients with hyperthyroidism by non-invasive left ventricular pressure-strain loop technology

WANG Mofeng; GAN Ling; ZHANG Jiaqi; YIN Jiabao

Abstract：Objective To evaluate the left ventricular systolic function in patients with hyperthyroidism by non-invasive left ventricular pressure-strain loop(LV-PSL)technology.Methods 91 patients with hyperthyroidism were enrolled in this study.The patients were then categorized into two groups:the initial diagnosis group(n=49)and the treatment group(n=42)based on whether treated or not.Additionally,healthy volunteers were included as the control group(n=40).Relevant parameters were as-sessed using conventional echocardiography,global longitudinal strain(GLS)was measured using speckle tracking technology,and the global work index(GWI),global constructive work(GCW),global wasted work(GWW),and global work efficiency(GWE)were obtained using LV-PSL technology.Statistical analysis was performed to compare the parameters among the three groups.Finaly,we analyzed the correlation between SBP,HR and GLS,GWI,GCW,GWW,and GWE.Results Compared with the control group,HR,AOEDD,and GWW were increased in both the initial diagnosis and treatment groups,while GLS,GWI,and GWE were decreased;and SBP was increased in the initial diagnosis group,while GCWwas decreased.The differ-ences were statistically significant(P<0.05).Compared with the initial diagnosis group,SBP,HR and GWW were decreased in the treatment group,while GWE was increased,the differences were statistically significant(P<0.05).Correlation analysis showed that SBP was positively correlated with GWW(r=0.277,P<0.01),SBP was negatively correlated with GLS and GWE(r=-0.271、-0.259,P<0.01);HR was negatively correlated with GLS and GWE(r=-0.220,-0.185,P<0.05),and also negatively cor-related with GWI and GCW(r=-0.447,-0.353,P<0.01).Conclusion Non-invasive LV-PSL technology can quantitatively evaluate left ventricular systolic function in patients with hyperthyroidism in the early stage and provide reference value for clini-cal early prediction,early intervention,and efficacy evaluation.After treatment,the left ventricular systolic function of patients with hyperthyroidism can be restored.