Ultrasound MicroPure imaging in diagnosis ofbreast cancer:A Meta-analysis

WU Feng; LI Yang; WANG Bing; JIN Peng

Abstract：Objective To evaluate the diagnosticvalue of ultrasound MicroPure imaging in breast cancer by Meta analysis.Methods The databases including PubMed,EMBASE,Web of science,Cochrane Library,China National Knowledge Infra-structure(CNKI),Wanfang Data,CBM and VIP were searched comprehensively and screened respectively for the related articles from establishment to March 2022.The quality evaluation of the included articles was performed by QUADAS-2 which was used for judgement of the risk of bias and,the feature information was appraised and extracted.Simultaneously,the comprehensive evaluation was applied by Meta-Disc and Stata 16.0 statistical software.First of all,the heterogeneity was estimated and the corre-sponding effect model was selected,and then the mean value of sensitivity,specificity and likelihood ratio and 95%confidence in-terval were obtained,the area under the curve(AUC)of summary receive operating characteristic(SROC)was calculated,and fi-nally the bias analysis was carried out.Results Including 18 articles,the studies had a total of 1647 cases and 1807 lesions.There was heterogeneity caused by non-threshold effect in the included studies.The random effects model analysis showed that the mean sensitivity and confidence interval(95%)was 83.00%(78.00%～87.00%),the mean specificity was 86.00%(81.00%～90.00%),and AUC was 0.91(0.88～0.93).The combined diagnostic odds ratio(DOR)was significant 29.00(17.00～51.00).The included articles were stable and the publication bias was not statistically significant(P=0.48>0.05).Conclusion Meta analysis indicates that ultrasound MicroPure imaging technology has not only higher sensitivity,but also higher specificity and accuracy in the diagnosis of breast cancer,which can provide valuable information particularly on breast cancer with calcification.