The value of ZOOMit IVIM-DWI and DKI in identifying different pathologic types of lung cancer

HE Yu; LIN Xiangtao; ZHAO Peng; ZHANG Wei; GUO Wenxiu; ZHANG Qi

Abstract：Objective To explore the value of quantitative parameters of small field of view intravoxel incoherent motion dif-fusion imaging(ZOOMit IVIM-DWI)and diffusion kurtosis imaging(DKI)in differentiating different pathological types of lung cancer.Methods Ninety-five cases of lung cancer hospitalized and pathologically confirmed in Shandong Provincial Hospital were collected as study subjects.According to cell type,the 95 cases of lung cancer were divided into two groups,i.e.,small cell lung cancer(SCLC)and non-small cell lung cancer(NSCLC).In detail,there were 79 cases of NSCLC,including 57 adenocar-cinomas,22 squamous carcinomas,and 16 cases of SCLC.The patients included in the study had completed preoperative imag-ing,and their pathologic results were obtained by surgery or puncture biopsy.ZOOMit IVIM-DWI and DKI sequential scans were performed before surgery,and the regions of interest were manually outlined as required to compare the differences in true diffu-sion coefficients(D-values),pseudo-diffusion coefficients(D*-values),perfusion fractions(f-values),mean kurtosis of diffu-sion(MK-values),and mean diffusion coefficients(MD-values)among different pathologic subtypes of lung cancers.The diag-nostic efficacy of the parameters was evaluated using a subject's work characteristic curve(ROC).Results The D,f,and MD values of NSCLC were greater than those of SCLC,and the MK values were smaller than those of SCLC,and the differences were statistically significant(P<0.05),and the areas under the differential diagnostic efficacy curves of each parameter were greater than 0.7(P<0.05),in which the D value of IVIM-DWI and the MD value of DKI were 0.903 and 0.912,respectively(P<0.001);and the differences of each parameter value between adenocarcinoma and squamous cancer were not statistically signifi-cant(P>0.05).The differences in the values of each parameter between adenocarcinoma and squamous carcinoma were not sta-tistically significant(P>0.05).None of the differences in D* values of IVIM-DWI in the differentiation of common pathologic types of lung cancer were statistically significant(P>0.05).Conclusion ZOOMit IVIM-DWI and DKI have some value in identifying the pathologic types of lung cancer,in which the diagnostic efficacy of the MD value of DKI and the D value of ZOOMit IVIM-DWI is higher than that of the other quantitative parameters,and the diagnostic specificity of the MD value of DKI is the highest.