Correlation between adipose tissue around left anterior descending artery and coronary heart disease evaluated by 320-slice coronary artery CTA

LIU Shuming; LI Sheng; GUAN Huiyuan; XIE Xingwu; CHEN Guangbin

Abstract：Objective To investigate the correlation between pericoronary adipose tissue(PCAT)and coronary heart disease(CHD)using 320-slice CT and semi-automatic image post-processing plug-in.Methods A total of 52 CHD patients with cul-prit lesions located in the left anterior descending artery(LAD)confirmed by coronary CTA and coronary angiography(CAG)were selected as the experimental group,and 59 patients with no obvious lesions were selected as the control group.The semi-automatic image post-processing plug-in was used to measure the PCAT volume and density from the LAD opening to the distal 40mm,and the related clinical baseline data and PCAT volume and density were compared between the two groups.Pearson cor-relation was used to analyze the correlation between PCAT volume and clinical data and hS-CRP.ROC curve was delineated to evaluate the optimal critical value of PCAT volume for diagnosis of CHD.Delineated box diagram and harp diagram were employed to depict the density distribution characteristics of the two groups of PCAT.Results The volume of PCAT in the experimental group was higher than that in the control group,the difference was statistically significant(P<0.05);ROC curve showed that the area under the curve(AUC)of PCAT volume in the diagnosis of CHD was 0.633.When the PCAT volume was 1871mm3,the sen-sitivity was 73.1%and the specificity was 52.5%,which showed the highest efficiency in the diagnosis of CHD;Pearson correla-tion analysis showed that PCAT volume was positively correlated with leukocyte count and hs CRP(r = 0.208,0.189,P<0.05);the average density of PCAT in the experimental group was(-88.35±5.08)Hu,and the average density of LAD in the control group was(-86.41±5.06)Hu.Compared with the control group,the density difference between the two groups was statistically significant(P<0.05),and the box diagram and Piano diagram described the dispersion and distribution characteristics of the density data of the two groups.Conclusion PCAT is related to the occurrence and development of CHD.