MRS study on changes in brain metabolites in migraine and their relationship with cognitive and emotions
YANG Jing
XU Longji
REN Fuxin
GAO Fei
Abstract：Objective This study aims to use MRS technology to investigate the changes in neurotransmitters in the brain of migraine patients and their relationship with cognitive and emotional changes.Methods Thirty-one migraine patients were selected as MA group and 28 healthy subjects as control group.Using MRS,we analyzed the changes of gamma-aminobutyric acid(GABA),glutamic acid(Glu)and glutathione(GSH)levels in anterior cingulate cortex(ACC),cerebellar dentate nucleus(DN)and left insula(LINS),and then,observed their correlation with cognitive performance,mood and migraine char-acteristics in migraine patients.Results Compared with the normal group,the MA group showed cognitive decline and anxiety increased;GSH level increased in ACC(P=0.010),GABA level decreased in DN(P=0.043)and LINS(P=0.029).In DN,GABA was negatively correlated with TMT_A(r=-0.542,P=0.002),while,in LINS,GABA was negatively correlated with MSQ(r=-0.441,P=0.017)and PHQ-9(r=-0.400,P=0.031).Conclusion This study provides a new perspective for the analy-sis of cognitive and emotional changes in migraine patients.
Keywords：MigraineMagnetic resonance imagingGamma-aminobutyric acidGlutathione
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 16-19 )