Magnetic Resonance Spectroscopy Study on Brain Metabolic Changes and Their Correlation with Cognitive Impair-ment in Patients with Postherpetic Neuralgia
ZHAO Min
HU Xin
LIU Yuxi
WANG Jing
REN Fuxin
GAO Fei
ZHAO Bin
Abstract：Objective This study aims to explore the correlation between neurotransmitter levels and cognitive functioning in individuals suffering from postherpetic neuralgia(PHN).Methods This study included 25 patients with PHN and 25 healthy volunteers.The cognitive function of all participants was assessed.The levels of GABA,GSH,and Glu in the anterior cingulate cortex(ACC)and the left insular cortex(LINS)were measured in the participants.Results 1)Reduced GABA levels and el-evated Glu levels were observed in the ACC of PHN group,with similarly increased Glu levels in the LINS.2)E/I intheACCof PHN grou pwas found to be associated with information processing speed.3)Elevated Glu/GSH were identified in both the ACC and LINS of PHN group.Conclusion The disruption of the GABAergic and glutamatergic systems within cognitive-related brain regions and the resulting E/I imbalance,as well as the redox imbalance,may be the metabolic factors contributing to cogni-tive impairment in patients with PHN.
Keywords：Postherpetic NeuralgiaBrain MetabolicCognitive ImpairmentMagnetic Resonance Spectroscopy
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 9-12 )