Difference of resting-state brain activity between premature ejaculation patients with and without depression

LIU Shaowei; CHEN Jianhuai; LI Jing; ZHONG Qingfang; YU Xiaoli

Abstract：Objective To explore the central mechanism of depression in PE patients from the perspective of neuroimaging.Methods The resting functional magnetic resonance imaging(rs-fMRI)data of 48 PE patients with depression(HAMD-17>7),48 PE patients without depression(HAMD-17≤7)and 40 healthy controls(HCs)(HAMD-17≤7)were collected.Reagional homogeneity(ReHo)values of 90 brain regions in the AAL template were calculated.The differences of ReHo values were com-pared by ANOVA and two sample t-test.The results were corrected by the AlphaSim program.Results(1)Compared with HCs,PE patients without depression showed decreased ReHo values in the left calcarine fissure,left superior occipital gyrus and left middle occipital gyrus;and increased ReHo values in the left insula and left caudate,the right postcentral gyrus and right gyrus rectus.(2)Compared with HCs,PE patients with depression showed decreased ReHo values in the left precuneus,left calcarine fissure,left superior occipital gyrus,left middle occipital gyrus,right middle temporal gyrus,right superior occipi-tal gyrus,right middle occipital gyrus and right cuneus;and decreased ReHo values in the left precuneus,left insula,left puta-men,left supplementary motor area,left paracentral lobule,left postcentral gyrus,left rolandic operculum,right postcentral gy-rus,right rolandic operculum,right caudate and right putamen.(3)Compared with PE patients without depression,PE patients with depression showed the decreased ReHo values in the left inferior parietal gyrus;and increased ReHo values in the anterior cingulate gyrus.Conclusion In PE patients,depression may be related to the decreased synchronicity of activity in the left in-ferior parietal gyrus and the increase in the left anterior cingulate gyrus,which lead to increased ability to feel and recognize negative emotions,and decreased ability to pay attention to and regulation of emotional external stimuli.