Correlation between ultrasonographic signs and molecular typing in small breast cancer

YU Xiaoqin; GUO Liang; WANG Junfang; ZUO Hengling; XU Ruiyun; CHEN Jinhua

Abstract：Objective To explore the correlation between ultrasonographic signs of small breast cancer and molecular typ-ing.Methods The sonographic features of 79 patients with 79 small breast malignant noplasms and axillary lymph nodes(23 with metastasis,56 without metastasis)were retrospectively analyzed.The results of ultrasonography were compared with pathol-ogy.The relationship between these signs and molecular typing were evaluated.Results In the 79 small breast malignant no-plasms,the Non-specific type of invasive breast cancer was the highest proportion,accounting for 62.03％(49/79).The type of Luminal B was the most common in the four molecular typing,accounting for 60.76％(48/79).The ultrasound lesion shape,edge,microcalcification,changes in the fascia,blood flow grade,and axillary lymph node metastasis were significantly differently to four molecular typings(P<0.05).The ultrasound lesion spiculated and changes in the fascia were statistically significant to Lumi-nal A and Basal typing(x2=3.909,4.232,P<0.05).The ultrasound lesion irregular and changes in the fascia were statistically sig-nificant to Luminal B and Basal typing(x2=17.719,4.232,P<0.05).The ultrasound lesion blood flow grade was statistically sig-nificant to basal and other three molecular typing(x2=6.134,7.023,6.806,P<0.05).Conclusions The ultrasound lesion shape,spiculated and changes in the fascia may diagnose Luminal typing.The ultrasound lesion microcalcification and axillary lymph node metastasis may diagnose HER-2 typing.Ⅱ-Ⅲ blood flow grade may diagnose Basal typing.The ultrasound signs of small breast cancer are correlated with their molecular subtypes,which can provide an important basis for clinical treatment and prognosis.