Association of SNAP-25 gene mnlI polymorphism with resting stage functional magnetic resonance imaging and working memory in boys with attention-deficit/ hyperactivity disorder
FANG Diangang
YANG Binrang
ZENG Hongwu
WANG Peng
LIANG Guohua
GAN Yungen
HUANG Rong
Abstract：Objective To investigate the association of SNAP-25 gene mnlI polymorphism with resting state brain eunction and working memory (WM) in boys with Attention-deficit/hyperactivity disorder (ADHD). Methods Resting stage functional magnetic resonance imaging was performed in 36 ADHD boys with TT homozygous genotype (TT group) and 20 ADHD boys with G allele (TG group). ReHo was used as a measure index. Two independent sample t-test was conducted to investigate the difference of ReHo values between the two groups. Wechsler Intelligence scale for Children (WISC-IV) was used to evaluate WM index of boys in the two groups. Two independent sample t-test was conducted to investigate different WM capacity between the two groups. The difference was statistically significant When P<0.05. Results 1. Compared with the TG group: 1) Increased ReHo values in TT group were found in: ① Default Mode Network: left posterior cingulate gyrus, left precuneus, right posterior cingulate, left medial superior frontal gyrus, right medial superior frontal gyrus, left middle temporal gyrus, right middle temporal gyrus; ② left superior frontal gyrus, left middle frontal gyrus, inferior frontal gyrus; ③ right middle frontal gyrus. 2) Decreased reHo values were found in: ① right postcentral gyrus, righ cerebellum posterior lobe; ② left Anterior cingulate, right Anterior cingulate; ③ left superior parietal gyrus. 2. WM in TT group was higher than that in TG group (P<0.05). Conclusion SNAP-25 gene MnlI polymorphism had different genetic impact on brain function in ADHD boys, and there were differences in WM between the two genotypes. f MRI can reveal possible basis from bran function network aspect.
Keywords：Attention-deficit/hyperactivity disorderSynaptosomal-associated protein 25Functional magnetic resonance imagingWorking memory
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 354-358 )