The value of ultrasonography in detecting NT thickening and venous catheter spectrum abnormality in the screening of fetal complex cardiac malformations

YE Chunxiu; ZHENG Na; LI Haiping; QI Yuxia; YU Tingqin

Abstract：Objective To investigate the value of detecting NT thickening and DV spectrum abnormality in early pregnancy in screening fetal complex cardiac malformations. Methods From September 2015 to September 2017, 5180 pregnant women, who had been performed prenatal examination in our hospital from September 2015 to September 2017 and were followed up to pregnancy outcome, were selected as study subjects. NT thickness and Doppler blood flow spectrum of venous ducts were measured in all pregnant women at 11136 weeks. Fetal echocardiography was performed by transvaginal (1516 weeks) or transabdominal (20～24 weeks) approach for fetuses with NT thickening and abnormal DV. The results were compared with those of autopsy and neonatal follow-up. Results Compared with NT normal fetus, NT thickened fetus was more susceptible to complex congenital heart defects (P＜0.05), with sensitivity of 81.25％, specificity of 95.17％, positive predictive value of 13.59％, negative predictive value of 99.82％, accuracy 95.04％; Compared with the normal fetus, the incidence of complex congenital heart malformation was significantly higher (P＜0.05), the sensitivity was 85.42％, the specificity was 95.58％, the positive predictive value was 15.30％, the negative predictive value was 99.86％, and the accuracy rate was 95.48％; by NT and DV abnormal fetus compared with NT or DV normal fetus, the incidence of complex congenital heart malformation was significantly higher (P＜0.05), the sensitivity was 68.75, the specificity was 98.46, the positive predictive value was 29.46, the negative predictive value was 99.7 and the accuracy was 98.19. Conclusion The detection of NT thickening and venous catheter spectrum abnormality in early pregnancy has important value in screening fetal complex congenital heart malformation.