Striatum changes in Parkinson's disease with mild cognitive impairment
LI Ying
JIA Xiuqin
LIANG Peipeng
LI Kuncheng
XU Lei
Abstract：Objective The present study aimed to examine the specific structural alterations in Parkinson's disease with mild cognitive impairment (PD-MCI). Methods Fifty patients with PD classified into 25 PD-MCI and 25 PD with no MCI (PD-NCI) and 25 healthy control (HC) ,who underwent T1-weighted structural MRI and neuropsychological assessments of five domains, were recruited in the present study. Voxel-based morphometry (VBM) analysis was performed to detect the structural atrophy in PD-MCI and its association with cognitive performance was further explored. Results Compared to PD-NCI and HC,reduced grey matter volume (GMV) was observed in the bilateral putamen and right caudate specifically for PD-MCI. Further,it was found that reduced GMV in the bilateral putamen was positively correlated with executive function and language performance,and decreased GMV in the right putamen /caudate was additionally positively correlated with memory. Conclusion PD-MCI exhibited specific basal ganglia atrophy,which was contributed to cognitive decline in PD. These findings suggest that basal ganglia alteration might be a potential biomarker for PD-MCI.
Keywords：Parkinson's diseaseMild cognitive impairmentBasal gangliaMagnetic resonance imaging
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1-6 )