Age-related differences in high resolution magnetic resonance imaging findings in patients with middle cerebral artery atherosclerotic stenosis
GAO Peihong
SHAO Sai
WANG Guangbin
LV Baotao
GONG Jian
WANG Xianjun
ZHAO Zhenyu
Abstract：Objective This study aimed to use high-resolution magnetic resonance imaging(HRMRI) to evaluate the correla-tion of age with vascular remodeling and plaque burden in patients with moderate-severe atherosclerotic middle cerebral artery (MCA) stenosis. Methods HRMRI and clinical characteristics of patients with atherosclerotic MCA stenosis having stenosis de-gree ≥50% diagnosed by magnetic resonance angiography were retrospectively analyzed. According to age,the patients were di-vided into young (≤45 years old) and middle–old groups ( >45 years old). Vessel and lumen areas in the maximal lumen narrowing and reference site were measured in the HR-T1WI axial image, and wall area, plaque size, stenosis degree, plaque burden percentage,and remodeling index were calculated. Remodeling index≥1.0 was considered as positive remodeling and <1.0 was considered as negative remodeling. Results The negative remodeling ratio in the young and middle-old groups was 80. 83 % and44.68 %(P =0.037),and the plaque burden percentage was0.314 ± 0.1 8 3 and0.4 0 5 ± 0.1 2 6,respectively ( P =0.017). Conclusion The remodeling pattern and plaque burden of MCA atherosclerotic stenosis were related to age. The negative remodeling ratio was higher in the young group than in the old group,and the plaque burden percentage was lower in the young group than in the old group.
Keywords：AgeAtherosclerosisMagnetic resonance imagingMiddle cerebral artery
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 525-528 )