The evaluation of QSM in therapeutic effect of Parkinson's disease by acupuncture treatment
LIN Wanmin
XU Zhifeng
PENG Xiaowen
Abstract：Objective To discuss the value of 3.0 T MR Quantitative Susceptibility Mapping(QSM) in response evaluation of Parkinson's disease (PD) by acupuncture treatment. Methods 21 PD patients were enrolled,all patients were diagnosed in neu-rology department and were divided into stages II~IV according to the improvement of Hoehn-Yahr scoring system. PD patients underwent acupuncture treatment for 6 courses,and were evaluated by UPDRs system and MR-QSM exmination before and after treatment. The brain iron deposition in the substantia nigra (SN) and lentiform nucleus (IN) were both evaluated. Matching t test was used in the statistical analysis of these data. Results Compared with before treatment,the uPDRs decreased greatly after acupuncture treatment ( P <0.01). In addition, the brain iron deposition in the SN and IN was significant decrease ( P <0.01). Conclusion Acupuncture treatment showed a good effect for PD treatment. QSM can provide objective and accurate evi-dence for the therapeutic effect evaluation of PD by acupuncture treatment.
Keywords：Parkinson's diseaseQuantitative susceptibility mappinAcupunctureMagnetic resonance imaging
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 521-524 )