The application of double low dose and perfusion imaging in the diagnosis of SPN with wide detector CT

WU Sumeng; SONG Yunlong; WANG Ping; CHEN Yi

Abstract：Objective To evaluate the clinical application of time-density curves(TDC) in diagnosis of SPN with 320-detec-ter computer tomography low-dose dual perfusion imaging. Methods There were 28 cases of SPN confirmed by pathological di-agnosis and successfully examined by 320-detecter computer tomography low-dose dual perfusion imaging, including first clinical patients and patients with non-surgical treatment after review. All CT examinations were performed using 320-detecter computer tomography (Aquilion ONE,Toshiba Medical Systems),a bolus of 40 ml contrast agent(Ultravist,370 mgI/ml),followed by 40 ml saline at a flow rate of 6 ml/sec. Scan data included 13 packets and all packets were analyzed with abdominal perfusion soft-ware,acquired pulmonary artery,bronchial artery,pulmonary nodules and descending aorta time-density curves. Results There were significant differences in rising time of TDC among malignant SPN,pulmonary artery and bronchial artery( P <0.05). The receiver operating characteristic(ROC) curve was 0.778,the critical value was 35.35 HU,the sensitivity and the specificity was 66.7% and 91.0%,respectively ( P <0.05). Conclusion 320-detecter computer tomography low-dose dual perfusion ima-ging provides objective blood supply situation of a nodule, and has important guiding role in diagnosis of benign and malignant SPN.