Correlation and clinical signification among 18F-FDG uptake level,the expression of nuclear antigen Ki-67 and staging of DLBCL
LIN Lejun
LI Shanchun
TAN Guiping
XU Zhiying
LI Weilong
YAO Xiaoqin
Abstract：Objective To discuss the correlation and clinical signification arnorg 18F-FDG uptake level,the expression of nu-clear antigen Ki-67 and staging of DLBCL. Methods We had retrospectively analyzed the imaging materials and results of 70 DLBCL patients,all the patients were diagnosed by the pathology and immunohistochemistry. Before the treatment, all the pa-tients had been examined by PET/CT routinely. Results The 18F-FDG average standard uptake value of DLBCL patients is posi-tively correlated with Ki-67,the correlation coefficient r is 0.843( P <0.001). There is a correlation between Ki-67 and staging ( P <0.001),the higher the index is,the more advanced the staging is. There is no correlation between 18F-FDG average stand-ard uptake value and staging. There is a statistical difference between Ki-67 expression level and tumor staging,largest tumor di-ameter,blood LDH level on DLBCL patients ( P <0.05),and there is no statistical difference with other clinical factors. Con-clusion There is a close relationship between Ki-67 and PET/CT in reflecting cell proliferation and invasion of the lesions on DL-BCL patients.
Keywords：Diffuse large Bcell lymphoma18 F-FDG
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 369-373 )