The relationship between emphysema severity and location of lung cancer in patients with chronic obstructive lung dis-ease
WANG Dawei
YANG Fei
ZHANG Zhenming
WEI Yulei
WANG Guigang
DONG Yuehua
ZHU Xiaolong
Abstract：Objective The purpose of this study was to determine the relationship between emphysema severity and location of lung cancer in patients with COPD. Methods 101 patients with primary lung cancers were included in the study.Of these,49 patients were with COPD. The emphysema severity were scored(0~4) on thinsection CT and the location of lung cancer was as-signed as peripheral or central. Results Patients with COPD had a higher proportion of age,male,incidence and severity of em-physema compared with those without COPD,and the difference was of statistically significant. Patients with COPD had a higher proportion of centrally located lung cancer (49.0% vs 28.8%,P <0.05). In patients with COPD,the proportion of central lo-cation was higher in patients with lower emphysema grades (0~2, < 25%) than in those with higher grades(3 ~4,>26%) (57.9% vs 18.2%,P <0.05). Conclusion The lung cancers in patients with COPD tended to be centrally located compared with patients without COPD. Lower emphysema grades seemed to be predictors of central location of lung cancer in COPD. There-fore,in patients with COPD with lower grade emphysema(airway-predominant disease),sputum and bronchoscopy may have to be considered for central lung cancer detection along with thin-section CT in order to detect of cancer earlier.
Keywords：Chronic obstructive pulmonary diseaseLung cancerEmphysemaTomographyX-ray computed
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 215-218 )