Cerebrovascular events and symptoms:a multimodal imaging study of moyamoya disease

MA Runlei; YE Ming; LU Lu

Abstract：Objective To determine the correlations between the moyamoya disease symptoms and the cerebrovascular lesions and collateral circulation by multi-modality imaging. Methods This study retrospectively analyzed 22 patients who had been re-corded and diagnosed with moyamoya disease in our hospital from 2010 to 2016. All patients were categorized into the intracranial hemorrhagic group or cerebral infarction group based on CT and MRI performance. Researchers made the classification and score according to the patients'CT or MRI performance. This study used DSA combined with CTA or MRA to classify collateral circula-tion. The study analyzed the clinical symptoms,intracranial lesions,age,and cerebrovascular events by correlation analysis after confirming no significant difference in the grouping. Results The intracranial hemorrhage group and infarction group in age,gen-der had no significant difference,except for the incidence of subarachnoid&ventricle group( P =0.008). The Spearman correla-tion coefficients between the hemorrhage group and subarachnoid&ventricle lesions group,the infraction group and subarachnoid& ventricle lesions group,lobar lesion location and infraction group were 0.516( P =0.014),-0.690( P =0.000),0.574( P=0.005),respectively. The Spearman correlation coefficient between age and consciousness disturbance,consciousness disturb-ance and headache,seizure and intellectual disturbance were 0.428( P =0.047),-0.542( P =0.009),0.690( P =0.000), respectively. The Spearman correlation coefficient between the stage classification and Muscle weakness, the basal ganglia and Muscle weakness were 0.506( P =0.016),0.436( P =0.043),respectively. The Spearman correlation coefficient between the second pathway and gender was 0.463( P =0.030). The pearson correlation coefficient between the third pathway and headache was 0.510( P =0.015). The pearson correlation coefficient of stage classification and scoring was 0.616( P =0.002). Conclu-sion The results suggested that the clinical symptom was associated with the lesion area and the stage classification in moyamoya disease. The clinical symptoms and collateral circulation type were related. These were worthy in the assessment of the clinical prognosis and prevention of complications.