The high risk factors of leukoaraiosis in maintenance dialysis patients and the value of 3.0TMRI diffusion functional im-aging

ZHU Gangming; LI Zhaoyong; QIN Daxian; TAO Juan; ZOU Yulin; LI Zhijuan; LIU Chengkang; CAI Yuefei

Abstract：Objective To investigate the high risk factors of leukoaraiosis in maintenance dialysis patients and the value of 3.0 TMRI diffusion functional imaging. Methods 75 patients with LA were taken as LA group and 43 patients without LA as non LA group. The general situation and biochemical indicators of the two groups of patients were statistically compared. The Statisti-cally significant data were analyzed by Logistic regression analysis and found out the independent risk factors of LA. LA group of patients were scanned by conventional MRI brain scan, DWI and DTI. Using ARWMC classification standard, the LA patients were divided into grade Ⅰ~ Ⅲ. Different grades of independent risk factors were statistically compared. There were significant differences in the risk factors and the ADC and FA values of LA patients main lobe were analyzed by Pearson correlation analysis. Results The independent risk factors of LA in maintenance dialysis patients were age, duration of dialysis, Cystatin C. There were statistical difference in the age and duration of dialysis of difference grades of LA patients( P <0.05). The level of cystatin C in LA patients with grade Ⅰ were significantly different from that in patients with grade Ⅱ and grade Ⅲ( P <0.05). The ADC and FA values of bilateral frontal,parietal,occipital white matter in LA patients were positively and negatively correlated with age and duration of dialysis. Conclusion The independent risk factors of LA in maintenance dialysis patients were age, duration of dialysis,Cystatin C. Diffusion functional imaging can reflect the characteristics and extent of LA objectively,sensitively and data-mation,and with the performance of independent high risk factors of cooperation.