18 F-FDG PET/CT characteristics of bone metastases from hepatocellular carcinoma
WANG Zhizhong
SU Jiagui
OUYANG Xiaohui
ZHOU Xiaohong
LIU Xiaofei
HE Baoming
Abstract：Objective Our study was to evaluate characteristics of bone metastases from HCC by 18F-FDG PET/CT.Methods 45 patients with bone metastasis(191 lesions)from hepatocellular carcinoma,who had undergone PET/CT,were evaluated.Ima-ging data were analyzed retrospectively based on FDG PET /CT imaging.Metastatic bone lesions were identified with visual inspec-tion on FDG PET/CT,and maximum standardized uptake value(SUVmax)was used for the quantitative analysis.Confirmation of bone metastasis was based on histopathology,combined imaging modalities,or serial follow-up studies.Results Bone metastases with soft tissue were found in 21 patients.Bone metastases were most frequently found in the spine,followed by the rib cage and pelvis.The major(143/191)form of bone destruction was osteolytic change,others(48/191)showed higher focal FDG uptake without bone destruction.64(33.5%)lesions presented with soft tissue formation showed higher uptake of FDG than lesion with-out soft tissue formation(6.56 ±3.64 vs 5.35 ±2.41,P =0.034).FDG PET was more effectively than CT in detecting lesions (98%vs 87%).Conclusion The most common radiographic feature of bone metastases from HCC is an osteolytic lesion,either replaced by soft tissue mass,FDG PET/CT is more sensitive than CT in bone metastasis from HCC.
Keywords：Hepatocellular carcinomaBone metastasesOsteolytic soft tissue formationFluorine-18-fluorodeoxyglucose
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2322-2325 )