The research of the hippocampus change in the MCI and AD patient by combining SWI with PET/CT
ZHAO Liang
ZHU Yan
KONG Qianqian
ZHOU Qun
LI Yuefeng
Abstract：Objective To explore the changes of the nerve cell glucose uptake in the hippocampus based on the abnormal ve -nous drainage among the normal elderly people , mild cognitive impairment ( MCI) and Alzheimer's disease ( AD) , from the aspect of venous to study its function of nerve cells .Methods We used subsequence of SWI and PET/CT to scan 15 normal elderly people, MCI and AD patients respectively and detected the Variation characteristics of the bilateral hippocampus draining veins and 18 F-FDG SUVmax changes in the bilateral hippocampus .Results Compared with the normal elderly people , the maximum diameter of left inferior ventricular vein is reduced significantly in MCI , the length and branch numbers are increased , but the SU-Vmax in the left hippocampus has no significant change;the maximum diameter , length, branch numbers and the SUVmax in off-side have no significant changes .Compared with the normal elderly people , the maximum diameter , length and branch numbers in bilateral inferior ventricular veins are reduced significantly in AD , and the SUVmax in the bilateral hippocampus is reduced signif-icantly.Conclusion The changes of the hippocampal draining veins form may lead to the disorder of glucose utilization in hipp -ocampal nerve cells , and there is a certain regular in the process from MCI to AD .
Keywords：Mild cognitive impairmentAlzheimer's diseaseHippocampusSusceptibility weighted imagingGlucose uptake
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1854-1857,1862 )