The localization value of 3.0T MR spectroscopy in children with temporal lobe epilepsy
LI Zhiyong
GAN Yungen
LIANG Guohua
ZHANG Gongwei
LUO Yizhen
WEN Jialun
SONG Jianming
Abstract：Objective To study the localization value of 3.0 T magnetic resonance spectroscopy ( 1 H-MRS) in children with temporal lobe epilepsy ( TLE) .Methods Conventional magnetic resonance imaging ( MRI) and 1 H-MRS were performed in 28 patients with TLE and 22 healthy volunteers .The NAA/Cr, NAA/Cho, NAA/( Cho+Cr) of hippocampus were calculated re-spectively and compared among the lesion group ,contralateral groop and control group .Results 11 out of 28 cases were found hippocampal volume loss , in 5 cases, the signal intensity of the hippocampus in the ipsilateral side of the lesion in FLAIR imaging was higher than the contralateral side .There was no statistically significant difference in NAA/Cr, NAA/Cho, NAA/(Cho+Cr) in the control subjects ( P >0.05).The NAA/Cr, NAA/Cho, NAA/(Cho+Cr) of the hippocampus in the ipsilateral side were 1.37, 1.16 and 0.64, lower than that in other groups ( P <0.05), but there was no statistically significant difference between the contralateral side and the control group ( P >0.05).Conclusion 1H-MRS can quantify biochemical metabolic disorders of TLE, which plays an important role in locating diagnosis of TLE in children .
Keywords：Temporal lobe epilepsyMagnetic resonance imaging
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1850-1853 )