Retrospective analysis of the results of glioma rescued the treatment with the implantation of magnetic resonance ima-ging-guided iodine-125 seeds and the exploration of the prognostic factors within one year
GUO Zongtong
LIU Ming
XU Yujun
HE Xiangmeng
LI Peipei
LIU Chao
LI Chengli
Abstract：Objective To analyze retrospectively the results of glioma treated with the implantation of iodine-125 seeds and to explore the prognostic factors within one year. Methods 31 evaluable glioma patients treated with the implantation of iodine-125 seed using a MR system with optical tracking navigation were studied retrospectively. Among them, 15 had Ⅲ-grade and 16 had Ⅳ-grade glioma. Gender, patient's age, Karnofsky scores, the longest diameter of the glioma, extent of resection, tumor histolo-gy, target dose D90, tumor location were factors influencing prognosis. Cumulative survival rates and influencing factors were ana-lyzed and compared using the life table method and Cox proportional hazard model. Results Univariate analysis showed that pa-tients with age≤50, Karnofsky scores≥80, extent of resection, tumor histology, target dose D90(90~100 Gy) before the im-plantation of iodine-125 seeds had better progonsis. The group discrepancies displayed statistical significance ( P <0. 05). By contrast, gender, the longest diameter of the glioma, tumor location showed no statistical signifcance ( P >0. 05). Conclusion Patients with age≤50, Karnofsky scores≥80, extent of resection, target dose D90(90~100 Gy) are factors for prognosis.
Keywords：125 I seedsTarget dose D90Magnetic resonanceGlioma
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1642-1645 )