Extratemporal abnormalities of brain parenchyma in young adults with temporal lobe epilepsy: a diffusion tensor ima-ging study
YIN Xiangyuan
XU Rui
LI Jianlong
WANG Ruimin
Abstract：Objective In this study, we evaluated extratemporal abnormalities in young adult patients with TLE utilizing DTI images. Methods We examined 20 young patients with unilateral TLE and 20 healthy controls using a 3. 0 T GE Signa EXCITE MR imaging scanner. Our ROIs included AIC, PIC, EC, HCN, LN, TL, FL, OL, CG, GCC, BCC, SCC. Four DTI parameters were used to quantitatively analyze the ROIs:FA, ADC,λ∥andλ⊥. Results In comparison to controls, TLE patients showed that FA was louer in all ROIs, ADC was higher in the bilateral ECs, HCNs, TLs and BCC,λ∥was louer in the ipsilateral LN, bilateral AICs, TLs, FLs, OLs, CGs and FR, GCC; and λ⊥ was higher in all the ROIs except the contralateral PIC. Using Pearson correlation analysis, we found a negative correlation between ADC of GCC and the epilepsy onset age, a positive correla-tion between ADC of GCC and the duration of epilepsy, a negative correlation betweenλ∥of ipilateral PIC and the epilepsy onset age, a negative correlation betweenλ⊥ of contralateral AIC and the duration of epilepsy, and a positive correlation betweenλ⊥of GCC and the duration of epilepsy. Conclusion DTI can be used to evaluate the extratemporal lobe changes in young patients with TLE noinvasively and effectively. The young patients with TLE with an younger onset age or longer duration of epilepsy have more serious extratemporal changes.
Keywords：TLE of young adultMagnetic resonance imagingDiffusion tensor imaging
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1636-1641 )