Early left ventricular dysfunction in patients with newly diagnosed obstructive sleep apnoea

WANG Tao; WANG Zhibin; WANG Yanli

Abstract：Objective To evaluate whether obstructive sleep apnea ( OSA) contributes directly to left ventricular ( LV) dias-tolic and regional systolic dysfunction in newly diagnosed OSA with normal left ventricle ejection fraction . Methods 125 consecutive patients were prospectively enrolled in the study .Control group consisted of 78 asymptomatic age-matched healthy subjects who did not have any cardiovascular and respiratory diseases .All patients had undergone overnight polysomnography and standard transthoracic and tissue Doppler imaging echocardiogram .Results The E/A ratio and the peak E wave at mitral flow were significantly lower and the peak A wave at mitral flow was significantly higher in OSA patients compared with control sub -jects.Left ventricle isovolumetric relaxation time ( IVRT) and mitral valve flow propagation ( MVFP) were significantly longer in OSA patients than in controls.Tissue Doppler derived S' amplitude of lateral part at mitral valve (S'Lm) and E' wave ampli-tudes both at the lateral ( E' Lm) and septal parts of the mitral valve ( S' Sm) were significantly lower in OSA patients compared to controls.Conclusion Newly diagnosed OSA patients with normal global LV function have significantly impaired diastolic func -tion and regional longitudinal systolic function .OSA is independently associated with these changes in LV function .