The role of real-time optimization of radioactive seed implantation in treatment of gliomas

HU Heying; WANG Hong; PENG Lijing; LIU Shifeng; HU Xiaokun

Abstract：Objective To study the role of real-time optimization of 125 I seed implantation in the treatment of gliomas .Meth-ods 38 cases were enrolled in this retrospective study .21 cases with 24 lesions involved from September 1st 2013 to September 30th 2015 were only performed preoperative planning and postoperative verification .17 cases with 21 lesions involved were addi-tional performed real-timeoptimization during the operation .D90, mPD, V90, V100, V150, V200, CI, EI, and HI were recor-ded.D90 and mPD were compared between preoperative planning and postoperative verification .V90, V100, V150, V200, CI, EI, and HI were compared with the inter-group postoperative verification .Paired t test was used to compare the difference within group .Independent sample test was used to compare the difference between groups .Results There was no difference in D 90 and mPD between preplan and postplan of group A , but were difference of group B.There were differences in V90, V100, V150, CI, EI, and HI of postplan between group A and group B but no difference in V 150 and V200.Conclusion Real-time optimization during operation could insure the good measure of preoperative planning to guarantee the reasonable distribution of postoperative dose and is of great value in the brachytherapy of brain tumors .