Value of high resolution MRI in the formation of moyamoya-like collateral vessels related disease at the base of the brain

DU Jiachen; ZHAO Peng; WANG Long; LI Fuyan; LI Hongxia; CUI Yi; ZHANG Mei

Abstract：Objective To explore the value of 3.0 T multiple high resolution MRI sequences in digital subtract angiograph (DSA) or magnetic resonance angiography (MRA), which found that the formation of moyamoya-like collateral vessels at the base of the brain.Methods The patients of this HR MRI research came from Qilu hospital of Shandong University ( we finally collect-ed 30 patients), all of these patients were scanned multiple sequences on a 3.0 T MRI, which consisted of routine brain MR se-quences (T1WI, T2WI, FLAIR, DWI), 3D-TOF-MRA and high resolution MRI sequences.The patients were divided into two groups with respect to the related standard:moyamoya disease (MMD) (n=17)and intracranial atherosclerotic disease-moyamoya syndrome (ICAD-MMS) (n=13).Characteristics were compared between the two groups , Which included unilateral or bilateral proximal of middle cerebral arteries were stenosis or occlusion , the type of intracranial lesions ( ischemia or hemorrhage ) and ste-nosis or occlusion of distal of the internal carotid arteries .All statistical analyses were performed with SPSS 17.0.Results 1) The MMD group (mean age 30.9 ±14.4 years) was younger on average than the ICAD-MMS group (mean age), P =0.001. There were no differences in sex between the two groups ( P =0.139);2) The two groups had no signoficance in occlusive or stenosis of unilateral or bilateral MCA ( P =0.242).The incidence of intracerebral hemorrhage in the MMD group was higher than ICAD-MMS group ( P =0.024).Stenosis or occlusion of internal carotid arteries was more common in MMD group ( P =0.007).Statistical significance was defined as a p-value less than 0.05.Conclusion High resolution MRI play an important role in exploring the pathogenesis of the formation of moyamoya-like collateral vessels which uncovered in DSA or MRA , and it provided additional crucial images in the process of the diseases , and has made it possible to diagnose MMD and ICAD-MMS by a noninvasive method .