Clinical characters and MRI diagnosis of malignant mesoderm mixed tumor

JIANG Minbo; YUAN Lin; FU Shilong

Abstract：Objective o explore analyze clinical and MR characters of malignant mesoderm mixed tumors ( MMMTs) so as to improve the understanding of this disorder .Methods The clinical manifestations and MR findings of 11 cases of MMMTs from the department of gynecology , the first affiliated hospital of Nanjing Medical University , which were confirmed by operation and pathology, were retrospectively analyzed in this work .Results By following up of 11 patients, the average of age was 56-year-old, the most common symptom was abnormal vaginal bleeding , especially, the postmenstrual bleeding, accounting for 80%~90%, and hypogastralgia, pelvic pain or, sometimes, vaginal discharges (water or soft tissue) always appeared.MR demonstra-ted the obvious soft tissue mass with signals of broken soft tissue inside , hetero-hypo-intensity in T1 WI, hetero-intensity or slight hyper-intensity in T2 WI, and mixed hyper-intensity in DWI.The mixed enhancement signal exhibited in early stage and mixed hy-po-intensity in late stage , which was lower than the enhancement of the myometrium .The growth of tumor was fast and formed a large mass during a short period of time , which was shown uneven signal in intensity .At the late stage , the patients suffered from ascites or metastasis, who presented with marasmus, fatigue, fever, and or so on.Conclusion For a woman in menopause, who presents with abnormal bleeding from vagina , abdominal distension or pain , MMMTs should be highly suspected .MRI is helpful for preoperative diagnosis of MMMTs .