A comparative function al MRI study on the abnormal attention function of patients with AD and MCI
LIHuanjing
LIU Zengshan
WANG Shuang
GEN G Bin
ZHANG Daguang
LIU Zhenwang
ZHANG Qing
Abstract：Objective To explore the abnormalities in the dorsal and ventral attention network of patients with AD and MCI . Methods Seventeen patients with AD , sixteen patients with MCI and sixteen normal aging participants underwent functional MRI scanning .After data preprocessing , independent component analysis was performed to extract the functional connectivity pattern of dorsal and ventral attention networks of three groups , and the between-group differences were calculated using one way analysis of variance .Results The dorsal attention network significantly differed in the left frontal eye fields , intraparietal sulcus area ,as well as posterior cingulate cortex , while, the ventral attention network significantly differed in the right ventral and dorsal middle /inferior frontal gyrus .Post hoc comparisons on the regions of interest revealed totally impaired attentional networks for patients with AD, whereas, selectively impaired attention networks for patients with MCI , with impaired connectivity in the dorsal system , but preserved connectivity in the ventral system .Conclusion The differed functional connectivity in the attention networks of patients with AD and MCI may be the neural mechanisms of behavioral attention deficits , reflecting the deterioration progress and neural compensation degree in the process of dementia .
Keywords：Alzheimer's diseaseMild cognitive impairmentDorsal attention networkVentral attention networkMagnetic resonance imaging
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 11-14,24 )