Imaging and clinical analysis of adult reversible splenial lesion syndrome

WANG Na; WANG Ping; FENG Juan

Abstract：Objective To investigate the clinical characteristics , imaging findings and laboratory biochemical results of revers-ible splenial lesion syndrome ( RESLES) in adult patients , and to carry out the clinical analysis .Methods We retrospectively analysed of 7 cases of adult patients whose clinical diagnosis were RESLES and were treated from January 2013 to January 2016 in Shengjing Hospital of China Medical University , and analysed the clinical characteristics , imaging, biochemical data, treatment and prognosis.Results Among the 7 cases, 4 were male, 3 were female, 5 had fever and headache, some cases were accompa-nied with symptoms such as disturbance of consciousness , visual disturbance , vomiting and so on .7 cases all underwent head MRI 3 to 14 days after the onset, which showed the abnormal signal of splenium of the corpus callosum (SCC), slightly low or low signal in T1WI, high or slightly high signal in T2WI and FLAIR, high signal in DWI and low signal in ADC, and no enhancement effect in all enhanced scan .According to the etiology of 7 cases of patients with targeted therapy , clinical symptoms were com-pletely remission in the 7 to 60 days after the onset , the lesion completely disappeared in the 10 to 45 days after the onset by re-viewed head MRI .Conclusion RESLES is a group of clinical imaging syndrome , its pathophysiological mechanism is still un-completely clear , etiology is complex , manifestation is various , but it has characteristic imaging findings , and targeted treatment according to different causes , the prognosis is well .