3D multi-voxel 1 H-MRS on substantia nigra of patients with PD
Abstract：Objective To study the Parkinson's disease of substantia nigra neuronal metabolites changes and its clinical signif -icance.Methods This study included 30 patients with PD, 20 healthy controls.All of subjects were examined with 3D multi-voxel 1H-MRS scan and obtained the substantia nigra metabolites relative ratio (NAA/Cr, NAA/Cho, NAA/(Cr+Cho).Then we compared the relative ratio of the PD group and the healthy control , the asymmerric PD group of bilateral , and the different grade PD group.Results 1) The PD group and healthy control NAA/Cr, NAA/Cho, NAA/(Cho+Cr) had obvious difference ( P <0.05); 2) The PD group limb contralateral and limb ipsilateral NAA/Cr, NAA/Cho, NAA/(Cho +Cr) had obvious difference ( P <0.05);3) The H-Y graded mild group and severe group of PD NAA/Cr, NAA/Cho, NAA/(Cho+Cr) had ob-vious difference ( P <0.05).Conclusion The PD substantia nigra metabolites had changes .the asymmerric PD group of bilat-eral had difference;the H-Y graded mild group and the heveier group had difference;The substantia nigra 1 H-MRS had the im-portant significance in the early diagnosis of PD .
Keywords：Parkinson's diseaseSubstantia nigraMagnetic resonance imagingMagnetic resonance spectroscopy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1949-1953 )