Clinical application of magnetic resonance diffusion tensor imaging in judging prognosis of acute ischemic cerebral in-farction

HU Jian-bin; CHEN Fei; GAN Min; WANG Xue-yang; XU Gang; YE-Yang

Abstract：Objective To evaluate the clinical application value of each parameter from magnetic resonance diffusion tensor imaging ( DTI) in judging prognosis of acute ischemic cerebral infarction .Methods We analysed each parameter images from DTI of 48 patients with unilateral acute ischemic cerebral infarction and more than 3 months follow up diagnosed by clinic and magnetic resonance imaging , divided the patients to three groups of favourable prognosis , general prognosis and bad prognosis ac-cording to the follow up results of modified Rankin scale ( mRS) , set the regions of interest ( ROI) of infarction lesions and the contra on DTI parameters mapping of fractional anisotropy (FA), volume ratio anisotropy (VRA), average diffusion coefficient (DCavg) and exponential attenuation (Exat), and recorded the parameters values of ROI and calculate the relative parameters value of infarction lesion to the contra .Meanwhile , we reconstructed the DTT images based on the seed points ( infarction lesion and the contra ) .We compared the differences of each parameter value between infarction lesions and the contra , also analysed the differences of relative parameters values of infarction lesion to contra among three groups .Results The DTT images of acute is-chemic cerebral infarction could show the manifestation of fasciculi damag .The FA, VRA and DCavg value of cerebral infarction lesions were lower and the Exat value was higher than the contra in each group ( P <0.05).The relative FA and VRA value of infarction lesion to the contra were gradually decreased from favourable prognosis to bad prognosis group ( P <0.05), but there were no differences of the relative FA value between favourable prognosis and general prognosis and the relative VRA value be -tween general prognosis and bad prognosis .The relative DCavg and Exat value were no difference among three groups .Conclu-sion The FA, VRA, DCavg and Exat value have specific change mode in acute ischemic cerebral infarction .Among them, the relative FA and VRA values of infarction lesions to the contra can be the strong basis for judging clinical prognosis .