Diagnosis of meningioma by MRI perfusion weighted imaging:Comparative analysis between dynamic contrast enhance-ment(DCE) and arterial spin labeling(ASL)

SU Sheng; ZHU Jianguo; XU Jie; HE Wenwen; TIAN Jun; HAN Huiyun; ZHAI Huajun; CAO Peng; WU Jiangfen

Abstract：Objective The diagnostic efficiency of different quantitative parameters in meningioma was compared between dy -namic contrast enhancement (DCE) and arterial spin labeling (ASL).Method s Twenty three cases of meningioma diagnosed by surgery and pathology were accepted MRI conventional scan and perfusion examination including DCE -MRI and ASL-MRI be-fore operation.The quantitative parameters were measured in the region of the tumor and the contralateral brain region .The differ-ence of the perfusion parameters in the tumor area and the contralateral area were counted by paired t test.The diagnostic efficacy of each parameter in the meningioma was evaluated using receiver operating characteristic (ROC) curves.Results The perfusion parameters was significant difference between the tumor area and the contralateral cerebral according paired t test , such as Ktrans:(0.329 ±0.207) min-1 vs.(0.003 ±0.003) min-1( P <0.001, Kep:(0.880 ±0.480) min-1 vs.(0.259 ±0.246) min-1( P<0.001, Ve:(0.421 ±0.294) vs.(0.060 ±0.071) ( P <0.001, Vp: (0.164 ±0.186) vs.(0.027 ±0.022) ( P =0.001), BV:(53.551 ±27.499) ml/100g vs.(5.279 ±3.870) ml/100g ( P <0.001, BF:(139.405 ±70.771) ml/100g. min vs.(22.336 ±21.099) ml/100g.min ( P <0.001, MTT:(0.395 ±0.110) s vs.(0.247 ±0.091) s ( P <0.001, TTP:(2.510 ±0.754) s vs.(1.381 ±0.506) s ( P <0.001, CBF:(85.300 ±51.786) ml/100g.min vs.(42.018 ±17.635) ml/100g.min ( P =0.001).The highest diagnostic efficiency parameters were Ktrans and BV .The cut-off point of the Ktrans was found to be 0.1640 min-1.This value provided the best trade-off between sensitivity (100%) and specificity (100%).The best cut-off point of BV was 16.518 ml/100g.At this level, sensitivity was 100% and specificity was 100%.The lowest diagnostic parameter was CBF (ASL-MRI).When cut-off point was 60.949 ml/100g.min, the specificity was 82.6% and the sensitivity was 73.9%.Conclusion More parameters and higher diagnostic efficiency can be got with DCE-MRI.The greatest advantage of ASL-MRI was without exogenous contrast agent .CBF can also be helpful to the diagnosis of meningioma , but the parameters of ASL-MRI was single and with much disturbed factors .