Multimodal fMRI resting-state functional connectivity in pontin e infarction

WANG Hui; CHEN Nan; LI Kuncheng; DUAN Xianggong

Abstract：Objective To investigate the brain function change of patients with pontine infarction with 3 fMRI resting-state functional connectivity measures .Methds The resting-state fMRI was acquired in 10 subacute pontine infarction patients and 10 normal controls .We firstly used degree centrality ( DC) and voxel-mirrored homotopic connectivity ( VMHC ) to analyze the data , got the main brain function change of patients that was used as the region of interest (ROI), then, we used ROI-based functional connectivity ( ROI-FC) to analyze the brain network change of patients .Results In DC, there is no effect , in VMHC, the pa-tients have significant decrease in connectivity between bilateral border region of inferior parital lobule and angular gyrus .Taking it as the ROI, in ROI-FC, the patients have brain function disorder mainly in default mode network ( DMN) and left frontoparietal network ( FPN) .Conclusion Combined with the application of different functional connectivity measures , the brain function of pontine infarction patients can be investigated at different levels , which can get reliable and clinically relevant information .