The short-term observation of clinical efficacy of 125 I seeds implantation in patients with glioma

WANG Yong-kui; LIU Shuai; HU Xiao-kun; LI Zi-xiang

Abstract：Objective To investigate the short‐term efficacy and safety of to investigate the 125 I seed implantation treat‐ment of glioma .Methods A retrospective analysis was perfomed in 32 patients with glioma ,who received CT‐guided 125 I radioactive seeds implantation therapy in the Affiliated Hospital of Qingdao University from Apr .2013 to Jun .2014 .The postoperative follow‐up was six months and the postoperative complications and efficacy were analyzed .Results None of 32 patients had no intracranial hemorrhage post -treatment .6 cases (18 .8% ) appeared postoperative nausea and vomi‐ting ,which were relieved after treatment with antiemetic and reducing the intracranial pressure .4 cases (12 .5% ) had slightly decreased peripheral blood leukocytes (not less than 3 × 109/L) ,which returned to normal after drug treatment . No significant changes in liver and kidney function were monitored before and after treatment .Follow -up of 125 I implanta‐tion was conducted for 2 months and 6 months (three half‐life) .The results among 32 patients after two -month were as follows :CR25 .0% (8/32) ,PR34 .4% (11/32) ,NC28 .1% (9/32) ,PD12 .5% (4/32) ,and efficiency (CR + PR) 59.4% .Those at 6 months were CR 34 .4% (11/32) ,PR37 .5% (12/32) ,NC21 .9% (7/32) ,PD6 .3% (2/32) ,and ef‐ficiency (CR + PR) up to 71 .9% .There were no deaths and cases of disease progression in 32 cases .Conclusion 125 I seeds implantation is a minimally invasive treatment for glioma ,which has a significant short‐term effect .