Combined the volume of hippocampus and the entorhinal cortex for identification of Alzheimer's disease and mild cognitive im-pairment
QIN Jia-wei
LI Hui-zhuo
LIANG Pei-peng
XIANG Jie
LI Kun-cheng
Abstract：Objective To improve the diagnostic accuracy of Alzheimer's disease (AD) and mild cognitive impairment (MCI) by combining the magnetic resonance imaging (MRI)‐based volume of hippocampus and the entorhinal cortex . Methods Brain regions were segmented based on MRI images for 133 AD patients ,305 MCI patients and 190 normal con‐trols (NC) ,and then ,the volumes of the bilateral hippocampus and entorhinal cortex were attained for all participants . The Logistic regression model was then used to combine them into a new joint index .Receiver operating characteristic curve (ROC) was utilized to evaluate the classification ability of the joint index and four single indexes (i .e .,the volume of the bilateral hippocampus and entorhinal cortex) .Results The volume of the bilateral hippocampus and entorhinal cor‐tex were significantly different between AD and NC( P<0 .05) ,MCI( P<0 .05) .The volume of the bilateral hippocam‐pus and left entorhinal cortex were significantly different between NC and MCI ( P <0 .05) .The area under ROC(AUC) of the new joint index for the classification of NC‐MCI ,NC‐AD ,and MCI‐AD were 0 .902 ,0 .987 ,and 0 .974 .Corre‐spondingly ,the classification accuracies of the new joint index were 84 .3% ,95 .1% ,and 92 .3% for the point with the optimal threshold ,with sensitivities and specificities over 80% ,which were higher than those of four single indexes .Con‐clusion The combination of the volume of hippocampus and the entorhinal cortex could significantly improve the diagnos‐tic accuracy of MCI and AD patients .
Keywords：Alzheimer's disease (AD)Mild cognitive impairment (MCI)Magnetic resonance imaging (MRI)Receiv-er operating characteristic curve (ROC)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1515-1519 )