Application of 18 F-FDG PET/CT in staging and therapeutic evaluation of patients with Hodgkin’s lymphoma

TAN Yi-jun; DING Chong-yang

Abstract：Objective To investigate the application of 18 F‐FDG PET /CT in clinical staging ,therapeutic evaluation ,re‐lapse monitoring and prognosis predicting of Hodgkin’s lymphoma .Methods A retrospective study was performed in 18 F‐FDG PET /CT for 51 patients with Hodgkin’s lymphoma from 2005 to 2011 in our hospital .PET /CT status was assessed for its ability to predict progression‐free survival (PFS) and overall survival (OS) .We used the chi‐square test and Kap‐lan‐Meierte analyze the data .Results 23 patients received PET /CT scan before treatment .After that ,the clinical staging of 4 patients (17 .4% ) increased .51 patients were performed 18 F‐FDG PET /CT after treatment .19 patients’ posttreat‐ment PET /CT results were positive ,and remaining 32 patients’ results were negative .The median PFS in patients with positive and negative group were 10 months and 38months ,the 2‐year PFS rate was 5 .2% (1/19) and 64 .5% (31) ,re‐spectively ;the median OS were 19 months and 39 months ,and the 3‐year OS rate was 10 .5% (2/19) and 51 .6% (16/31) ,respectively ,all being of significant difference between two groups (χ2 = 16 .978 , P = 0 .000 ;χ2 = 8 .631 , P =0.003 ,respectively ) .The positive predictive value and negative predictive value of posttreatment PET /CT were 94 .7%(18/19) ,90 .6% (29/32) ,respectively .Conclusion 18 F‐FDG PET /CT should be advantaged in clinical staging ,thera‐peutic evaluation ,relapse monitoring and prognosis predicting of Hodgkin’s lymphoma .It can help the clinic to make a early decision on therapeutic effects and set a personalized treatment plan .