18 F-FDG PET/CT imaging and VEGF expression in diagnosis of lung cancer prognosis
ZHOUXiao-liang
DENGHao-yu
LIXin-hui
WUWu-lin
LOUMing-wu
MOYi
XIEAi-ming
Abstract：Objective To analyse the association betweeen 18 F‐FDG absortion and the expression level of VEGF in NSCLC .The value evaluation of SUV and VEGF expression in tumor recurrence after resection of lung cancer were slud‐ied .Methods 40 patients with non small cell lung cancer (20 squamous cell carcinoma ,14 adeno carcinoma and 6 adeno‐squamous carcinoma) underwent whole‐body PET/CT imaging .After taken measurement of mass averaged SUV ,tumor tissue was detected by VEGF immunohistochemistry .By using Mattern semi quantitative analysis method ,tumor tissue VEGF expression for the total score was caulated .In non small cell lung cancer VEGF expression score and SUV were statistically analyzed .Results 40 cases of non small cell lung cancer tissue VEGF expression was significantly correlated with SUV ,the higher VEGF score ,the higher SUV ,r=0 .478 ,P<0 .01 .Postoperative follow‐up cases within half year relapse group and recurrence group mass organization mean SUV (6 .78 ± 2 .62) was significantly higher than that of the non recurrent group (3 .85 ± 1 .33) ,VEGF scores (4 .51 ± 1 .45) were significantly higher than those in non recurrent group (2.48 ± 1 .71) ,P values were <0 .05 .Conclusion VEGF expression of non‐small cell lung cancer is higher ,the postoperative recurrence and /or metastasis is more likely .The expression of VEGF score can be considered as a reference index and prognosis in patients with recent review .
Keywords：Non-small cell lung cancer (NSCLC)Vascular endothelial growth factor (VEGF)Standardized uptake value(SUV)Positron emission tomography/computer tomography(PET/CT)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 811-814 )